Cajun Chicken Pasta Bake

Featured in: Comfort Home Dishes

This dish combines tender pieces of chicken seasoned with bold Cajun spices, cooked with bell peppers and onions for a flavorful base. A creamy blend of mozzarella, cheddar, and Parmesan cheeses melts into a rich sauce, binding the pasta together. Baked to perfection, the casserole delivers a comforting, cheesy meal with a kick. Garnished with fresh parsley, it suits gatherings and hearty dinners alike.

Updated on Sat, 15 Nov 2025 12:02:00 GMT
Golden, bubbly Cajun Chicken Pasta Bake fresh out of the oven, with a rich cheesy topping. Pin this
Golden, bubbly Cajun Chicken Pasta Bake fresh out of the oven, with a rich cheesy topping. | recipeshood.com

A vibrant, comforting casserole featuring tender chicken, spicy Cajun seasonings, creamy sauce, and melty cheese, all baked with pasta for a crowd-pleasing meal.

I first made this Cajun Chicken Pasta Bake when my family wanted a meal with a little kick and tons of comfort. It quickly became a favorite for its hearty portions and satisfying blend of spices and cheese.

Ingredients

  • Chicken breasts: 2 large, cut into bite-sized pieces
  • Red bell pepper: 1, diced
  • Yellow bell pepper: 1, diced
  • Red onion: 1 small, diced
  • Garlic: 2 cloves, minced
  • Penne or rigatoni pasta: 300 g (10 oz)
  • Olive oil: 2 tbsp
  • Butter: 1 tbsp
  • Heavy cream: 200 ml (¾ cup)
  • Milk: 120 ml (½ cup)
  • Mozzarella cheese: 100 g (1 cup), shredded
  • Parmesan cheese: 50 g (½ cup), grated
  • Cheddar cheese: 100 g (1 cup), shredded
  • Cajun seasoning: 1½ tbsp, plus extra for garnish
  • Smoked paprika: ½ tsp
  • Salt: ½ tsp
  • Black pepper: ¼ tsp
  • Chili flakes: ¼ tsp (optional, for extra heat)
  • Fresh parsley: 2 tbsp, chopped

Instructions

Preheat:
Set your oven to 200℃ (400℉).
Cook the pasta:
Boil pasta in salted water for 2 minutes less than the package instructions. Drain and set aside.
Brown the chicken:
In a large skillet, heat olive oil and butter over medium-high. Add chicken, 1 tbsp Cajun seasoning, salt, and pepper. Sauté until browned and cooked through, about 6-8 minutes. Remove chicken and set aside.
Cook vegetables:
In the same skillet, add onions and bell peppers. Cook 4-5 minutes until softened. Add garlic, smoked paprika, and chili flakes (if using). Sauté 1 minute.
Make the sauce:
Lower heat to medium. Pour in cream and milk, stirring to scrape the skillet. Simmer 2-3 minutes.
Add cheeses:
Add ¾ of mozzarella, cheddar, and Parmesan. Stir until melted and smooth.
Combine chicken & pasta:
Return chicken to skillet, add cooked pasta, and toss to coat. Adjust seasoning as needed.
Transfer to baking dish:
Spread mixture in a greased baking dish. Top with remaining cheese.
Bake:
Bake 18-20 minutes, until cheese is golden and bubbly.
Garnish and serve:
Top with parsley and extra Cajun seasoning before serving.
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This dish was a huge hit at our last family dinner, and everyone came back for seconds. It brings a little Louisiana-inspired spice and a lot of comfort to the table.

Serving Suggestions

Serve your Cajun Chicken Pasta Bake with a simple green salad or warm garlic bread for a complete meal. A crisp Sauvignon Blanc or iced tea pairs perfectly with the spice and creaminess.

Allergen & Diet Notes

This recipe contains milk and wheat. Check labels for gluten in pasta and Cajun spice blends, and swap the pasta for a gluten-free variety if needed.

Storage & Reheating

Store leftovers in an airtight container in the fridge for up to 3 days. Reheat in the oven at 180℃ (350℉) until piping hot, or in the microwave for quick lunches.

A steaming plate of creamy Cajun Chicken Pasta Bake, featuring tender chicken and colorful bell peppers. Pin this
A steaming plate of creamy Cajun Chicken Pasta Bake, featuring tender chicken and colorful bell peppers. | recipeshood.com

Cheesy, spicy, and easy to make, this Cajun Chicken Pasta Bake will turn any dinner into a festive feast. Enjoy every bite with family and friends!

Frequently Asked Recipe Questions

What pasta types work best for this bake?

Penne or rigatoni are ideal as their tubular shapes hold the creamy sauce well during baking.

Can I adjust the spice level?

Yes, increase or reduce Cajun seasoning and chili flakes to match your preferred heat intensity.

How to ensure the chicken stays tender?

Cook chicken pieces over medium-high heat until browned but not overdone, then bake briefly to finish cooking with pasta.

What can I substitute for heavy cream?

Half-and-half can be used for a lighter texture, maintaining creaminess without too much richness.

Is it possible to add more vegetables?

Absolutely, ingredients like sliced mushrooms or spinach complement the dish and add extra nutrients.

Cajun Chicken Pasta Bake

Tender chicken and spicy Cajun seasoning blend with creamy sauce and cheese in a baked pasta dish.

Prep Duration
20 min
Time to Cook
35 min
Overall Time
55 min
Created by Julia Harris


Level of Challenge Medium

Cuisine Type American (Cajun-inspired)

Servings Made 4 Number of Portions

Dietary Details None specified

What You'll Need

Meats

01 2 large chicken breasts, cut into bite-sized pieces

Vegetables

01 1 red bell pepper, diced
02 1 yellow bell pepper, diced
03 1 small red onion, diced
04 2 cloves garlic, minced

Pasta

01 10 ounces penne or rigatoni pasta

Sauces & Dairy

01 2 tablespoons olive oil
02 1 tablespoon butter
03 ¾ cup heavy cream
04 ½ cup milk
05 1 cup shredded mozzarella cheese
06 ½ cup grated Parmesan cheese
07 1 cup shredded cheddar cheese

Spices & Seasonings

01 1½ tablespoons Cajun seasoning, plus extra for garnish
02 ½ teaspoon smoked paprika
03 ½ teaspoon salt
04 ¼ teaspoon black pepper
05 ¼ teaspoon chili flakes (optional)

Garnish

01 2 tablespoons chopped fresh parsley

Method

Step 01

Preheat oven: Set oven temperature to 400°F (200°C).

Step 02

Cook pasta: Boil salted water and cook pasta 2 minutes less than package instructions, then drain and set aside.

Step 03

Sauté chicken: Heat olive oil and butter in a large skillet over medium-high heat. Add chicken, 1 tablespoon Cajun seasoning, salt, and black pepper. Cook until browned and cooked through, about 6 to 8 minutes. Remove from skillet and set aside.

Step 04

Cook vegetables: In the same skillet, sauté diced red onion and bell peppers for 4 to 5 minutes until softened. Add minced garlic, smoked paprika, and chili flakes if using; cook for an additional minute.

Step 05

Prepare sauce: Reduce heat to medium and stir in heavy cream and milk, scraping up browned bits from the pan. Simmer for 2 to 3 minutes.

Step 06

Incorporate cheeses: Add three-quarters of mozzarella, cheddar, and Parmesan cheeses to the sauce, stirring until melted and smooth.

Step 07

Combine ingredients: Return chicken to skillet, add cooked pasta, and toss everything together to coat evenly. Adjust seasoning with additional Cajun seasoning, salt, or pepper as desired.

Step 08

Assemble casserole: Transfer mixture to a lightly greased baking dish and sprinkle remaining cheeses evenly on top.

Step 09

Bake: Bake in preheated oven for 18 to 20 minutes until cheese is golden and bubbling.

Step 10

Garnish and serve: Sprinkle with chopped parsley and a pinch of Cajun seasoning before serving.

Kitchen Tools Needed

  • Large skillet or sauté pan
  • Medium saucepan
  • 2-quart baking dish
  • Wooden spoon
  • Chef's knife and cutting board

Allergen Details

Review every ingredient for allergens and reach out to a professional if you're unsure.
  • Contains milk and wheat; gluten caution due to pasta.

Nutrition Details (per portion)

Nutrition info is for reference purposes only and isn't medical advice.
  • Energy (Calories): 670
  • Fats: 32 g
  • Carbohydrates: 56 g
  • Proteins: 40 g